Lauren Polstein

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Education

  • Degree: PhD in BME, 2015
  • Advisor: Charles Gersbach
  • Research Project: Light-Inducible Gene Regulation in Mammalian Cells

Research Interests

PUBLICATIONS

  1. Polstein, L. R. and C. A. Gersbach (in Press). A light-inducible CRISPR/Cas9 system for control of endogenous gene activation. Natural Chemical Biology, 2015.
  2. Polstein, L. R., Perez-Pinera, P., Kocak, D., Vockley, C., Bledsoe, P., Song, L., Safi, A., Crawford, G., Reddy, T., and Charles A. Gersbach (Under review). Genome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors. Genome Research, 2015.
  3. Polstein, L. R. and C. A. Gersbach (in Press). Light-Inducible Gene Regulation with Engineered Zinc Finger Proteins. In Methods in Molecular Biology: Photoswitching Proteins. Humana Press.
  4. Perez-Pinera, P., Kocak, D., Vockley, C., Adler, A., Kabadi, A., Polstein, L. R., Thakore, P., Glass, K., Ousterout, D., Leong, K., Guilak, F., Crawford, G., Reddy, T., and C. A. Gersbach, RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat Meth, 2013.
  5. Polstein, L. R. and C. A. Gersbach, Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors. Journal of the American Chemical Society, 2012.
  6. Polstein, L. R. and Gersbach C. A. (in Press). Spatiotemporal Genetic Control of Cellular Systems. In Tissue and Organ Regeneration: Advances in Micro and Nanotechnology. Pan Stanford Publishing Pte Ltd

 

POSTERS

  1. Polstein, Lauren R. and Gersbach, Charles A. Light-inducible spatiotemporal gene regulation using engineered transcription factors. Poster session presented at: Gene Regulation. 15th Annual American Society of Gene and Cell Therapy Conference: 2012 May 16-19; Philadelphia, PA.

 

ORAL PRESENTATIONS

  1. Polstein, Lauren R. and Gersbach, Charles A. Spatiotemporal Control of Mammalian Gene Regulation Using a Light-Inducible Recombinase. Oral presentation presented at: Federation of American Societies For Experimental Biology (FASEB): 2014 June 22-27: Nassau, Bahamas.
  2. Polstein, Lauren R. and Gersbach, Charles A. Light-Inducible Genetic Control in Human Cells. Oral presentation presented at: Pathway Engineering. Keystone Symposia Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways. 2013 March 17-22; Breckenridge, CO.
  3. Polstein, Lauren R. and Gersbach, Charles A. Light-Inducible Genetic Control in Human Cells. Poster presentation and rapid fire talk presented at: Society for Biological Engineering International Conference on Biomolecular Engineering. 2013 January 13-16; Ft. Lauderdale, FL
  4. Polstein, Lauren R. and Gersbach, Charles A. Light-Inducible Spatiotemporal Gene Activation Using Engineered Zinc Finger Transcription Factors. Oral presentation presented at: New Fronteirs and Special Topics. Biomedical Engineering Society Annual Conference; 2012 October 24-27; Atlanta, GA.
  5. Polstein, Lauren R. and Gersbach, Charles A. Light-Inducible Spatiotemporal Gene Activation Using Engineered Zinc Finger Transcription Factors. Oral presentation presented in: Tissue Regeneration Technology and Translation category. North Carolina Tissue Engineering and Regenerative Medicine; 2012 September 10; Raleigh, NC

 

AWARDS

  1. Federation of Amer. Societies for Experimental Biology (FASEB) Genome Engineering: Cutting-Edge Research Application Conference Travel Award (Nassau, Bahamas June 22-27). (2014)
  2. Keystone Symposia Precision Cenome Engineering and Synthetic Biology: Designing Genomes and Pathways Conference Travel Award (Breckenridge, CO March 17-22). (2013)
  3. Society for Biological Engineering International Conference on Biomolecular Engineering Travel Award (Ft. Lauderdale, FL January 13-16). (2013)