Education
- Degree: BME in BME, 2015
- Advisor: Mark Dewhirst, Greg Palmer, Mike Therien
- Research Project: Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
Research Interests
PUBLICATIONS
- C. L. Hofmann, W. Qi, C. D. Landon, M.J. Therien, M. W. Dewhirst, P. P. Ghorochchian, G. M Palmer, Self-Assembling PEG-b-P(TMC-co-CL) Near-Infrared Emissive Polymersomes for Pharmacokinetics, Toxicity Anaylsis, and Noninvasive Imaging of Tumor Accumulation, Biomaterials (2015) In Preparation.
- B. L. Viglianti, M. W. Dewhirst, R. J. Boruta, J. Y. Park, C. D. Landon, A. N. Fontanella, J. Guo, A. Manzoor, C. L. Hofmann, G. M. Palmer. Systemic anti-tumour effects of local thermally sensitive liposome therapy, International Journal of Hyperthermia, 30(2014) 385-392.
- M. W. Dewhirst, C. D. Landon, C. L Hofmann, P. R. Stauffer. Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes, Surg Oncol Clinics N Am, 22 (2013): 545-561.
POSTERS
- C. L. Hofmann, J. Yewle, K. Ashcraft, M. J. Therien, M. W. Dewhirst, P. P. Ghoroghchian, G. M. Palmer, Tumor Delivery of Polymersome-Encapsulated Myoglobin Results in Rapid Intratumoral Hemorrhaging, 12th International Nanomedicine & Drug Delivery Symposium, Chapel Hill, NC (October 2014 - Best Abstract Award), 2nd Annual Duke Cancer Institute Scientific Retreat (November 2014), Durham, NC.
- Hofmann CL, Qi Wei, Landon CD, Therien MJ, Dewhirst MW, Palmer GM, In Vitro Drug Release and In Vivo Tumor Delivery of Near-Infrared Emissive Biodegradable Polymersomes Containing Poly(ethylene glycol) and Randomized Poly(trimethylen carbonate-co-caprolactone), Controlled Release Society Annual Meeting, Honolulu, Hawaii (July 2013).
- Hofmann CL, Qi Wei, Landon CD, Therien MJ, Dewhirst MW, Palmer GM, Pharmacokinetics and Tumor Accumulation of Near-Infrared Emissive Polymersomes Composed of Poly(ethylene glycol) and Random Poly(caprolactone-co-trimethylene carbonate), Fitzpatrick Institute for Photonics (FIP) 2013 Annual Meeting (March 2013 - 2nd Place Poster Award), Radiation Oncology & Imaging Program Annual Retreat (March 2013), Annual Kewaunee Lecture and Poster Session (April 2013), 1st Annual Duke Cancer Institute Scientific Retreat (May 2013), Durham, NC.
- Hofmann C.L, Qi W, Gill T, Ghoroghchian P, Palmer GM, Therien MJ, Dewhirst MW, Pharmacokinetics and Biodistribution Analysis Using Near-Infrared Emissive Polymersomes, American Association for Cancer Research Molecular Targets and Cancer Therapeutics Conference, San Francisco, CA (November 2011), Annual Kewaunee Lecture and Poster Session, Duke University (April 2012).
- Hofmann CL, Qi W, Gill T, Ghoroghchian P, Palmer GM, Therien MJ, Dewhirst MW, Polymersomes Containing Near-Infrared Emitting Porphyrins for In Vivo Imaging, Annual Kewaunee Lecture and Poster Session, Duke University (April 2011).
- Hofmann CL, Qi W, Gill T, Ghoroghchian P, Palmer GM, Therien MJ, Dewhirst MW, Polymersomes Containing Near-Infrared Emitting Poryphyrins, Radiation Oncology & Imaging Program Annual Retreat, Duke University (February 2011).
ORAL PRESENTATIONS
- Hofmann CL, Qi W, Gill T, Ghoroghchian P, Palmer GM, Therien MJ, Dewhirst MW, Pharmacokinetics and Biodistribution of NIR-Emissive Biodegradable Polymersomes: Accumulation within Mammary Carcinomas, World Biomaterials Congress, Chengdu, China (June 2012).
- C. L. Hofmann, J. Yewle, K. Ashcraft, M. J. Therien, M. W. Dewhirst, P. P. Dewhirst, G. M. Palmer, Tumor Delivery of Polymersome-Encapsulated Myoglobin Results in Rapid Intratumoral Hemorrhaging, 12th International Nanomedicine & Drug Delivery Symposium, Chapel Hill, NC.
AWARDS
- Best Abstract Award, 12th International Nanomedicine & Drug Delivery Symposium, Chapel Hill, NC.
- Center for Biomolecular and Tissue Engineering Service Award (2013)
- CRS Outstanding Preclinical Sciences & Animal Health Best Paper Ward (2013)
- 2nd Place Poster Award Fitzpatrick Institute for Photonics (FIP) Annual Meeting (2013)