Amy Lynn McNulty

Associate Professor in Orthopaedic Surgery

The McNulty Lab is working to develop strategies to prevent osteoarthritis and to promote tissue repair and regeneration following joint injury. In order to accomplish this, we are working in three main areas.  1) We are working to understand the pathways that are activated by normal and injurious mechanical loading of cartilage and meniscus and how these mechanotransduction pathways are altered during aging, injury, and tissue degeneration. A greater understanding of alterations in mechanosensitive signaling mechanisms with aging and injury will likely reveal potential targets to promote tissue repair and prevent tissue degeneration and osteoarthritis development. 2) We are developing meniscus tissue engineered constructs that will be utilized to repair and replace meniscus tissue lost due to injury and surgical resection.  3)  We are focusing on the biological and biomechanical changes that occur in the joint following meniscus injury and how these may contribute to osteoarthritis development.   

Appointments and Affiliations

  • Associate Professor in Orthopaedic Surgery
  • Associate Research Professor of Cell Biology
  • Associate Professor of Biomedical Engineering
  • Associate Professor in the Department of Pathology
  • Affiliate of the Duke Regeneration Center

Contact Information

  • Office Location: 355A MSRB1, Durham, NC 27710
  • Office Phone: +1 919 684 6882
  • Email Address:


  • Ph.D. Duke University, 2005

Courses Taught

  • PATHOL 793: Research Independent Study
  • BME 791: Graduate Independent Study

In the News

Representative Publications

  • Betsch, Kevin, Vianna G. Martinez, Lucas P. Lyons, J Brice Weinberg, Jocelyn R. Wittstein, and Amy L. McNulty. “Shedding light on the effects of blood on meniscus tissue: the role of mononuclear leukocytes in mediating meniscus catabolism.” Osteoarthritis Cartilage, May 21, 2024.
  • Zhao, Qi, Abigail Holt, Charles E. Spritzer, Louis E. DeFrate, Amy L. McNulty, and Nian Wang. “High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.” Quant Imaging Med Surg 14, no. 4 (April 3, 2024): 2738–46.
  • Coppock, James A., Amy L. McNulty, Kathryn N. Porter Starr, Abigail G. Holt, Michael S. Borack, Andrzej S. Kosinski, Amber T. Collins, Connie W. Bales, and Louis E. DeFrate. “The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.” Osteoarthr Cartil Open 5, no. 3 (September 2023): 100376.
  • Andress, Benjamin, Maureane Hoffman, and Amy L. McNulty. “Analytical validation and quality control/quality assurance practices for improved rigor and reproducibility of biochemical assays in orthopaedic research.” J Orthop Res 41, no. 7 (July 2023): 1618–23.
  • Bradley, Patrick X., Karl N. Thomas, Avery L. Kratzer, Allison C. Robinson, Jocelyn R. Wittstein, Louis E. DeFrate, and Amy L. McNulty. “The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.” Curr Rheumatol Rep 25, no. 2 (February 2023): 35–46.