Andrew F. Adler

Education:

Degree: PhD in BME, 2013

Advisor: Kam W. Leong

Research Project: Non-viral Transfection and Direct Reprogramming of Fibroblasts to Neurons and Glia: Importance of Physical and Chemical Microenvironments

Research Interests:

PUBLICATIONS

  1. Perez-Pinera P, Kocak DD, Vockley CM, Adler AF, Kabadi AM, Polstein LR, Thakore PI, Glass KA, Ousterout DG, Leong KW, Guilak F, Crawford GE, Reddy TE, . RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nature Methods. 2013 Jul. PMID: 23892895
  2. Christoforou N, Chellappan M, Adler AF, Kirkton RD, Wu T, Addis RC, Bursac N, . Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. Plo S One. 2013 Jan;8(5):e63577. PMCID: PMC3660533
  3. Adler AF, Grigsby CL, Kulangara K, Wang H, Yasuda R, . Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells. Molecular therapy. Nucleic Acids. 2012 Jan;1:e32. PMCID: PMC3411320 
  4. Adler AF, Speidel AT, Christoforou N, Kolind K, Foss M, . High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts. Biomaterials. 2011 May;32(14):3611-9. PMCID: PMC3052739
  5. Adler AF, . Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery. Nano Today. 2010 Dec;5(6):553-569. PMCID: PMC3048656
  6. Adler AF, Petersen LK, Wilson JH, Torres MP, Thorstenson JB, Gardner SW, Mallapragada SK, Wannemuehler MJ, Narasimhan B, “High Throughput Cell-based Screening of Biodegradable Polyanhydride Libraries”, Combinational Chemistry & High Throughput Screening. 2009 Aug, 12(7), 634-45. PMCID: PMC305273
  7. Adrew F. Adler, Alessondra T. Speidel, Nicolas Christoforou, Kirsitan Kolid, Morten Foss, Kam W. Leong, High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts, Biomaterials, Volume 32, Issue 14, May 2011, 3611-3619.
  8. Le DM, Kulangara K, Adler AF, Leong KW, Ashby VS, Dynamic Topographical Control of Mesenchymal Stem Cells by Culture on Responsive Poly-caprolactone Surfaces, Advanced Materials, 2011 Aug, 23(29), 3278-3283.
  9. Andrew F. Adler, Kam W. Leong, Emerging links between surface nanotechnology and endocytosis: Impact on nonviral gene delivery, Nano Today, December 2010, 5(6), 553-569.
  10. Adler AF, Peterson LK, Wilson JH, Torres MP, Thorstenson JB, Gardner SW, Mallapragada SK, Wannemuehler MJ, Narasimhan B, "High Throughput Cell-based Screening of Biodegradable Polyanhydride Libraries", Comb Chem High Throughput Screen, 2009 Aug, 12(7), 634-45.
  11. Syandan Chakraborty, I-Chien Liao, Andrew Adler, Kam W. Leong, Electrohydrodynamics: A facile technique to fabricate drug delivery systems, Advanced Drug Delivery Reviews, Volume 61, Issue 12, Nanofibers in Regenerative Medicine and Drug Delivery, 5 October 2009, 1043-1054.
  12. Laura De Laporte, Alyssa Huang, Melissa M. Ducommum, Marina L. Zelivyanska, Misael O. Aviles, Andrew F. Adler, Lonnie D. Shea, Patterned transgene expression in multiple-channel bridges after spinal cord injury, Acta Biomaterials, Volume 6, Issue 8, August 2010, 2889-2897.

 

POSTERS

  1. Andrew F. Adler, Alessondra T. Speidel, Nicolas Christoforou, Kristian Kolind, Morten Foss, Kam W. Leong, Enhancement of transfection efficiency with substrate topography: high throughput discovery, Duke Synthetic Biology Symposium, April 16, 2011
  2. Andrew F. Adler, Alessondra T. Speidel, Nicolas Christoforou, Kristian Kolind, Morten Foss, Kam W. Leong, Enhancement of transfection efficiency with substrate topography: high throughput discovery, BME Departmental Retreat, May 12, 2011
  3. Andrew F. Adler, Alessondra T. Speidel, Kristian Kolind, Morten Foss, Kam W. Leong, Modulation of transfectability with substrate topography: emerging links to endocytosis, BMES Annual Meeting, October 8, 2010
  4. Andrew F. Adler, Kam W. Leong, Modulation of transfection and endocytosis by substrate topography, Kewaunee Event, April 8, 2010

 

ORAL PRESENATIONS

  1. Andrew F. Adler, Alessondra T. Speidel, Nicolas Christoforou, Kristian Kolind, Morten Foss, Kam W. Leong, Enhancement of transfection efficiency with substrate topography: Reverse transfection and siRNA, BMES Annual Meeting, October 14, 2011
  2. Andrew F. Adler, Alessondra T. Speidel, Nicolas Christoforou, Kristian Kolid, Morten Foss, Kam W. Leong, Enhancement of transfection efficiency with substrate topography: high throughput discovery, BME Departmental Retreat, May 12, 2011

 

AWARDS

  1. NSF GRF Fellowship Honorable Mention (2010)
  2. BME Annual Retreat Best Poster Award (2011)