Madeleine Sitton

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Madeleine earned her BS in Chemical and Biological Engineering at the University of Colorado Boulder in 2018. She is a PhD student in Charlie Gersbach’s lab working on developing CRISPR treatments for monogenic diseases.

Contact Information:

  • Email Address: madeleine.sitton@duke.edu

Research Interests:

Genetic Engineering, Gene Therapy, Synthetic Biology

 Publications: 

  • Pickar-Oliver, Black, Lewis, Mutchnick, Klann, Gilcrest, Sitton, Nelson, Barrera, Bartelt, Reddy, Beisel, Barrangou & Gersbach (in press). Targeted Transcriptional Modulation with Type I CRISPR-Cas Systems in Mammalian Cells. Nature Biotechnology.
  • Otoupal, Cordell, Bachu, Sitton & Chatterjee (2018). Multiplexed deactivated CRISPR-Cas9 gene expression perturbations deter bacterial adaptation by inducing negative epistasis. Communications Biology, 1(1), 129.

Presentations/Posters:

  • *Pickar-Oliver, Black, Lewis, Mutchnick, Klann, Gilcrest, Sitton, Nelson, Barrera, Bartelt, Reddy, Beisel, Barrangou & Gersbach (2019). Targeted Transcriptional Modulation with Type I CRISPR-Cas Systems in Mammalian Cells. Oral presentation to be given at the 3rd International Conference on CRISPR Technologies, Würzburg, Germany.
  • *Pickar-Oliver, Black, Lewis, Mutchnick, Klann, Gilcrest, Sitton, Nelson, Barrera, Bartelt, Reddy, Beisel, Barrangou & Gersbach (2019). Targeted Transcriptional Modulation with Type I CRISPR-Cas Systems in Mammalian Cells. Oral presentation given at the American Society of Gene & Cell Therapy, Washington D.C.
  • Sitton, Otoupal, Cordell & Chatterjee(2017). Engineering sequence-specific control over bacterial translation rates using deactivated Cas13a fused to IF1. Poster presentation at the University of Colorado, Boulder, Boulder, CO.
  • Sitton (2017). Project 1: Inventory Management Solution for Pilot Plant Filling Operations and Project 2: Overcoming Head Pressure Effects on Fill Volume. Poster presentation at Genentech Inc., South San Francisco, CA.
  • Sitton, Otoupal & Chatterjee (2016). Engineering Synthetic Genomic Devices Using CRISPR Technology to Control Bacterial Translation. Oral presentation at the University of Colorado, Boulder, Boulder, CO.
  • Sitton, Weinstein, Sarkar, Rentz & Greenlee (2013). Water Filtration Efficiency of Iron-Nickel Nanoparticle Enhanced Polyethersulfone Membranes. Poster presentation at the National Institute of Standards and Technology.
  • Sitton, Turner & Sparagna (2013). The Correlation Between Cardiolipin and its Function in Aerobic and Anaerobic Organs and Tissues. Poster presentation at the CordenPharma Regional Science Fair.

*denotes presentation given by co-author, not applicant