The Duke Center for Biomolecular and Tissue Engineering (CBTE) is a multidisciplinary center for training and research.
Duke CBTE is Duke University's most comprehensive efforts in biotechnology.
The mandate of Duke CBTE is to nucleate interdisciplinary research and educational activities that link three broad areas of biotechnology:
- Biomolecular engineering
- Cellular engineering
- Tissue engineering
Research With Impact
Biomolecular engineering in Duke CBTE concerns the design of proteins, oligopeptides, nucleic acids, and other biomolecules that elicit specific ligand-receptor interactions or that can be used to develop targeted drug therapies.
Cellular engineering in the center concerns the regulation of the external and internal environment of cells for promoting specific expression of biomolecules, improving drug and gene delivery, or facilitating tissue engineering.
The purpose of tissue engineering at Duke CBTE is two-fold:
- The design or modification of matrices that promote or inhibit specific interactions with proteins, cells, and tissues, and
- The production of ordered ensembles of cells for tissue replacement, disease modeling, or drug screening.
Biomolecular, cellular and tissue engineering are, themselves, intimately linked, and many CBTE research activities encompass all three. For example, cells condition surfaces through secretion of extracellular matrix proteins; ligand binding to receptors at membrane surfaces regulates cell activity; and preconditioning of surfaces with proteins and other biomolecules mediates cell function.
Our Multidisciplinary Faculty
Although centered in the Pratt School of Engineering, CBTE faculty members work in the Duke University Medical Center, or have primary or secondary appointments in at least one of these degree-granting academic departments:
- Biomedical Engineering
- Biostatistics and Bioinformatics
- Cell Biology
- Civil and Environmental Engineering
- Mechanical Engineering and Materials Science
- Orthopaedic Surgery
- Radiation Oncology