Evan Kurt

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Evan graduated with his B.S. in Chemical Engineering from Villanova University in 2017, followed by his M.S. in Biochemical Engineering in 2018 at Villanova. He is currently a PhD student in the Segura Lab, studying methods for gene therapy from hydrogel scaffolds.

Contact Information:

  • Email Address: evan.kurt@duke.edu

Research Interests:

Research Interests:

Non-viral gene delivery from flowable linked irregular particle (FLIP) scaffolds for tissue repair in ischemic stroke. Enhance polyplex loading in hyaluronic acid hydrogels using caged polymer formulations of minicircle DNA and mRNA. Optimize transfection from FLIP scaffolds in 3D culture and in vivo mouse models.

 Publications:

  • Truong, N. F., Kurt, E., Tahmizyan, N., Cai Lesher-Pérez, S., Chen, M., Darling, N. J., Xi, W. & Segura, T. Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer. Acta Biomater. (2019). doi:10.1016/J.ACTBIO.2019.02.054
  • Truong, N. F., Lesher-Pérez, S. C., Kurt, E. & Segura, T. Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds. Bioconjug. Chem. acs.bioconjchem.8b00696 (2018). doi:10.1021/acs.bioconjchem.8b00696
  • Kurt, E. Ex Vivo T Cell Capture, Growth, Characterization, and Modification for CAR T Cell Therapy. ProQuest. (Villanova University, 2018). ISBN:9780355911169
  • Spivack, K., Muzzelo, C., Neely, C., Vanzelli, J., Kurt, E. & Elmer, J. Small Molecule Inhibition of the Innate Immune Response Increases Transgene Expression. bioRxiv 338707 (2018). doi:10.1101/338707

Posters:

  • Non-viral Gene Delivery From Microporous Annealed Particle (MAP) Scaffolds; Nature Biomedical Engineering (May 2019)
  • Non-viral gene delivery from flowable linked irregular particle (FLIP) scaffolds using optimized CnE-formulated polyplexes; BMES (2019)