Pranam D. Chatterjee

Assistant Professor of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor of Biomedical Engineering
  • Assistant Professor in Biostatistics & Bioinformatics
  • Assistant Professor of Computer Science
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 101 Science Drive, CIEMAS 2353A, Durham, NC 27705
  • Email Address: pranam.chatterjee@duke.edu
  • Websites:

Education

  • Ph.D. Massachusetts Institute of Technology, 2020

Research Interests

Integration of computational and experimental methodologies to design novel proteins for applications in genome editing, targeted protein modulation, and reproductive bioengineering

Courses Taught

  • EGR 393: Research Projects in Engineering
  • COMPSCI 590: Advanced Topics in Computer Science
  • COMPSCI 394: Research Independent Study
  • COMPSCI 393: Research Independent Study
  • BME 791: Graduate Independent Study
  • BME 789: Internship in Biomedical Engineering
  • BME 590: Special Topics in Biomedical Engineering
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 390L: Special Topics with a Lab

In the News

Representative Publications

  • Peng, Fred Zhangzhi, Chentong Wang, Tong Chen, Benjamin Schussheim, Sophia Vincoff, and Pranam Chatterjee. “PTM-Mamba: a PTM-aware protein language model with bidirectional gated Mamba blocks.” Nature Methods, April 2025. https://doi.org/10.1038/s41592-025-02656-9.
  • Hong, Lauren, Tianzheng Ye, Tian Z. Wang, Divya Srijay, Howard Liu, Lin Zhao, Rio Watson, et al. “Programmable protein stabilization with language model-derived peptide guides.” Nature Communications 16, no. 1 (April 2025): 3555. https://doi.org/10.1038/s41467-025-58872-6.
  • Patel, Sawan, Fred Zhangzhi Peng, Keith Fraser, Adam D. Friedman, Pranam Chatterjee, and Sherwood Yao. “EvoFlow-RNA: Generating and Representing non-coding RNA with a Language Model.” Cold Spring Harbor Laboratory, February 28, 2025. https://doi.org/10.1101/2025.02.25.639942.
  • Torres, Marcelo D. T., Tianlai Chen, Fangping Wan, Pranam Chatterjee, and Cesar de la Fuente-Nunez. “Generative latent diffusion language modeling yields anti-infective synthetic peptides.,” February 1, 2025. https://doi.org/10.1101/2025.01.31.636003.
  • Vincoff, Sophia, Shrey Goel, Kseniia Kholina, Rishab Pulugurta, Pranay Vure, and Pranam Chatterjee. “FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking.” Nature Communications 16, no. 1 (February 2025): 1436. https://doi.org/10.1038/s41467-025-56745-6.