Lingchong You

Professor of Biomedical Engineering

The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine.

Appointments and Affiliations

  • James L. Meriam Distinguished Professor of Biomedical Engineering
  • Professor of Biomedical Engineering
  • Director of the Center for Quantitative Biology and Machine Learning
  • Professor in Molecular Genetics and Microbiology

Contact Information

Education

  • B.S.E. Chengdu University of Science and Technology (China), 1994
  • M.S. University of Science and Technology of China (China), 1997
  • Ph.D. University of Wisconsin, Madison, 2002

Research Interests

Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome

Awards, Honors, and Distinctions

  • Fellow. American Institute for Medical and Biological Engineering. 2019
  • Faculty Early Career Development (CAREER) Program. National Science Foundation. 2010
  • Young Professor Award. DuPont. 2008
  • Fellowships for Science and Engineering. David and Lucile Packard Foundation. 2006

Courses Taught

  • MGM 593: Research Independent Study
  • EGR 393: Research Projects in Engineering
  • CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 713S: QBio Seminar Series
  • BME 590: Special Topics in Biomedical Engineering
  • BME 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 394: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Tsoi, Ryan, Hye-In Son, Grayson S. Hamrick, Katherine Tang, Jonathan H. Bethke, Jia Lu, Rohan Maddamsetti, and Lingchong You. “A predatory gene drive for targeted control of self-transmissible plasmids.” Science Advances 11, no. 14 (April 2025): eads4735. https://doi.org/10.1126/sciadv.ads4735.
  • Kim, Kyeri, Andrea Weiss, Helena R. Ma, Hye-In Son, Zhengqing Zhou, and Lingchong You. “Antibiotic-mediated microbial community restructuring is dictated by variability in antibiotic-induced lysis rates and population interactions.” Nature Communications 16, no. 1 (March 2025): 2299. https://doi.org/10.1038/s41467-025-57508-z.
  • Son, Hye-In, Grayson S. Hamrick, Ashwini R. Shende, Kyeri Kim, Kaichun Yang, Tony Jun Huang, and Lingchong You. “Population-level amplification of gene regulation by programmable gene transfer.” Nature Chemical Biology, January 2025. https://doi.org/10.1038/s41589-024-01817-9.
  • Ma, Helena R., Helen Z. Xu, Kyeri Kim, Deverick J. Anderson, and Lingchong You. “Private benefit of β-lactamase dictates selection dynamics of combination antibiotic treatment.” Nature Communications 15, no. 1 (September 2024): 8337. https://doi.org/10.1038/s41467-024-52711-w.
  • Dai, Yifan, Zhengqing Zhou, Wen Yu, Yuefeng Ma, Kyeri Kim, Nelson Rivera, Javid Mohammed, et al. “Biomolecular condensates regulate cellular electrochemical equilibria.” Cell, September 2024, S0092-8674(24)00909-7. https://doi.org/10.1016/j.cell.2024.08.018.