Sharon Gerecht

Paul M. Gross Distinguished Professor

Gerecht’s research group studies how the microenvironment regulates cellular responses, with the long-term goal of developing countermeasures and therapeutics. We develop biomaterials and culture systems to emulate mechanical and physical stressors toward understanding tissue function, reliance, and homeostasis. We also use that information to uncover pathways in injury and disease development to guide tissue healing and regeneration. We focus on blood vessels and their multifaceted roles in tissue performance, aging, and disease. 

Appointments and Affiliations

  • Paul M. Gross Distinguished Professor
  • Professor of Biomedical Engineering
  • Associate Dean for Research and Infrastructure in the Pratt School of Engineering
  • Member of the Duke Cancer Institute

Contact Information

Education

  • Ph.D. Israel Institute of Technology (Israel), 2004

Research Interests

stem cells, biomaterials, hypoxia, blood vessels, physics of cancer, regenerative medicine

Awards, Honors, and Distinctions

  • Member. National Academy of Inventors. 2020
  • Fellow. American Association for the Advancement of Science (AAAS). 2020
  • Member. National Academy of Medicine. 2019
  • Invitee. Inaugural 2019 NAM Emerging Leaders Forum. 2019
  • Recipient. Patrick C. Walsh Prostate Cancer Research Fund. 2017
  • Fellow. American Institute for Medical and Biological Engineering (AIBME). 2016
  • Scholar. Inaugural Kent Gordon Croft Investment Management Faculty Scholar. 2015
  • Inaugural President's Frontier Award. Johns Hopkins University. 2015
  • National Established Investigator Award. American Heart Association. 2015
  • Heart Award. W.W. Smith Charitable Trust. 2014
  • CAREER Award. National Science Foundation (NSF). 2011
  • Junior Investigator Award. North American Vascular Biology Organization (NAVBO). 2009
  • Basil O’Connor Starter Scholar Research Award. March of Dimes Foundation. 2009
  • National Scientist Development Award. American Heart Association. 2008
  • Allan C. Davis Medal, Outstanding Young Engineering Award. Maryland Academy of Sciences. 2008

Courses Taught

  • BME 890: Advanced topics for PhD students
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 644: Physiology for Engineers
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 394: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Hall, Franklyn D., Christine N. Miller, Sharon Gerecht, and Kenneth R. Boheler. “Generation of an induced pluripotent stem cell line, JHUi005-A, from a Marfan Syndrome patient harboring a pathogenic c.3338-2A>C intronic splicing variant.” Stem Cell Research 79 (June 2024): 103475. https://doi.org/10.1016/j.scr.2024.103475.
  • Fuller, Ashley M., Hawley C. Pruitt, Ying Liu, Valerie M. Irizarry-Negron, Hehai Pan, Hoogeun Song, Ann DeVine, et al. “Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment.” The Journal of Clinical Investigation 134, no. 11 (April 2024): e167826. https://doi.org/10.1172/jci167826.
  • Wei, Zhao, Meng Lei, Yaohui Wang, Yizhou Xie, Xueyong Xie, Dongwei Lan, Yuanbo Jia, et al. “Author Correction: Hydrogels with tunable mechanical plasticity regulate endothelial cell outgrowth in vasculogenesis and angiogenesis.” Nature Communications 15, no. 1 (April 2024): 3274. https://doi.org/10.1038/s41467-024-47722-6.
  • Marino-Bravante, Gloria E., Alexis E. Carey, Laura Hüser, Agrani Dixit, Vania Wang, Amanpreet Kaur, Ying Liu, et al. “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma.” Nature Aging 4, no. 3 (March 2024): 350–63. https://doi.org/10.1038/s43587-024-00581-8.
  • Tran, Avery T., Emily O. Wisniewski, Panagiotis Mistriotis, Konstantin Stoletov, Maria Parlani, Alice Amitrano, Brent Ifemembi, et al. “Cytoplasmic accumulation and plasma membrane association of anillin and Ect2 promote confined migration and invasion.” Res Sq, January 10, 2024. https://doi.org/10.21203/rs.3.rs-3640969/v1.