Michael D Lynch

W. H. Gardner, Jr. Associate Professor of Biomedical Engineering

Appointments and Affiliations

  • W. H. Gardner, Jr. Associate Professor of Biomedical Engineering
  • Associate Professor in the Department of Biomedical Engineering
  • Associate Professor in Chemistry
  • Associate of the Duke Initiative for Science & Society

Contact Information


  • Ph.D. University of Colorado, Boulder, 2005
  • M.D. University of Colorado, School of Medicine, 2007

Research Interests

Focused on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds—improving production of biofuels, pharmacological molecules and industrial chemicals.

Courses Taught

  • EGR 393: Research Projects in Engineering
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering
  • BME 590L: Special Topics with Lab
  • BME 493: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Li, Shuai, Zhixia Ye, Eirik A. Moreb, Romel Menacho-Melgar, Maximillian Golovsky, and Michael D. Lynch. “2-Stage microfermentations.” Metabolic Engineering Communications 18 (June 2024): e00233. https://doi.org/10.1016/j.mec.2024.e00233.
  • Decker, John S., Utsuki Yano, Romel Menacho Melgar, and Michael D. Lynch. “Phase separation methods for protein purification: A meta-analysis of purification performance and cost-effectiveness.” Biotechnology Journal 19, no. 4 (April 2024): e2400005. https://doi.org/10.1002/biot.202400005.
  • Decker, John, Utsuki Yano, Romel Menacho Melgar, and Michael Lynch. “Precipitation and Extraction Methods for Protein Purification: A Meta-Analysis of Purification Performance and Cost-Effectiveness.” BioRxiv, 2023. https://doi.org/10.1101/2023.12.14.571684.
  • Hennigan, Jennifer, Romel Menacho-Melgar, Payel Sarkar, and Michael Lynch. “Scalable, Robust, High-throughput Expression, Purification & Characterization of Nanobodies Enabled by 2-Stage Dynamic Control.” BioRxiv, 2023. https://doi.org/10.1101/2023.12.14.571655.
  • Yang, Tian, Zhixia Ye, and Michael D. Lynch. “"Multiagent" Screening Improves Directed Enzyme Evolution by Identifying Epistatic Mutations.” ACS Synthetic Biology 11, no. 5 (May 2022): 1971–83. https://doi.org/10.1021/acssynbio.2c00136.