Lingchong You

Professor of Biomedical Engineering

The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine.

Appointments and Affiliations

  • James L. Meriam Distinguished Professor of Biomedical Engineering
  • Professor of Biomedical Engineering
  • Director of the Center for Quantitative Biology and Machine Learning
  • Professor in Molecular Genetics and Microbiology

Contact Information

Education

  • B.S.E. Chengdu University of Science and Technology (China), 1994
  • M.S. University of Science and Technology of China (China), 1997
  • Ph.D. University of Wisconsin, Madison, 2002

Research Interests

Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome

Awards, Honors, and Distinctions

  • Fellow. American Institute for Medical and Biological Engineering. 2019
  • Faculty Early Career Development (CAREER) Program. National Science Foundation. 2010
  • Young Professor Award. DuPont. 2008
  • Fellowships for Science and Engineering. David and Lucile Packard Foundation. 2006

Courses Taught

  • PHARM 394: Research Independent Study
  • MGM 593: Research Independent Study
  • EGR 393: Research Projects in Engineering
  • CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 713S: QBio Seminar Series
  • BME 590: Special Topics in Biomedical Engineering
  • BME 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 394: Projects in Biomedical Engineering (GE)
  • BIOLOGY 293-1: Research Independent Study

In the News

Representative Publications

  • Ha, Yuanchi, Helena R. Ma, Feilun Wu, Andrea Weiss, Katherine Duncker, Helen Z. Xu, Jia Lu, Max Golovsky, Daniel Reker, and Lingchong You. “Data-driven learning of structure augments quantitative prediction of biological responses.” PLoS Computational Biology 20, no. 6 (June 2024): e1012185. https://doi.org/10.1371/journal.pcbi.1012185.
  • Şimşek, Emrah, Kyeri Kim, Jia Lu, Anita Silver, Nan Luo, Charlotte T. Lee, and Lingchong You. “A 'rich-get-richer' mechanism drives patchy dynamics and resistance evolution in antibiotic-treated bacteria.” Molecular Systems Biology, June 2024. https://doi.org/10.1038/s44320-024-00046-5.
  • Luo, Nan, Jia Lu, Emrah Şimşek, Anita Silver, Yi Yao, Xiaoyi Ouyang, Stuart A. West, and Lingchong You. “The collapse of cooperation during range expansion of Pseudomonas aeruginosa.” Nature Microbiology 9, no. 5 (May 2024): 1220–30. https://doi.org/10.1038/s41564-024-01627-8.
  • Hamrick, Grayson S., Rohan Maddamsetti, Hye-In Son, Maggie L. Wilson, Harris M. Davis, and Lingchong You. “Programming Dynamic Division of Labor Using Horizontal Gene Transfer.” ACS Synthetic Biology 13, no. 4 (April 2024): 1142–51. https://doi.org/10.1021/acssynbio.3c00615.
  • Li, Zongru, Qionghua Shen, Emery T. Usher, Andrew P. Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, et al. “Phase transition of GvpU regulates gas vesicle clustering in bacteria.” Nature Microbiology 9, no. 4 (April 2024): 1021–35. https://doi.org/10.1038/s41564-024-01648-3.