Emily R. Derbyshire

Eads Family Professor

The Derbyshire Lab uses both chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens to exploring biological pathways and identifying small molecules with potential therapeutic value. Their interdisciplinary collaborative program integrates chemical biology, molecular biology and biochemistry to globally interrogate parasite biology.

Appointments and Affiliations

  • Eads Family Professor
  • Professor of Chemistry
  • Associate Professor of Molecular Genetics and Microbiology
  • Associate Professor of Cell Biology
  • Associate of the Duke Initiative for Science & Society

Contact Information

  • Office Location: 3218 French Science Center, Durham, NC 27708
  • Office Phone: +1 919 660 1511
  • Email Address: emily.derbyshire@duke.edu
  • Websites:

Education

  • B.S. Trinity College, 2002
  • Ph.D. University of California, Berkeley, 2008
  • Harvard Medical School, 2014

Courses Taught

  • MGM 593: Research Independent Study
  • MGM 293: Research Independent Study I
  • CHEM 89S: First-Year Seminar
  • CHEM 517: Molecules in Life and Disease
  • CHEM 494: Research Independent Study
  • CHEM 493: Research Independent Study
  • CHEM 401: Analytical Chemistry
  • CHEM 394: Research Independent Study
  • CHEM 393: Research Independent Study

In the News

Representative Publications

  • Lu, Kuan-Yi, Charisse Flerida A. Pasaje, Tamanna Srivastava, David R. Loiselle, Jacquin C. Niles, and Emily Derbyshire. “Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death.” ELife 9 (September 2020): e56773. https://doi.org/10.7554/elife.56773.
  • Ganley, Jack G., Ashmita Pandey, Kayla Sylvester, Kuan-Yi Lu, Maria Toro-Moreno, Sina Rütschlin, James M. Bradford, et al. “A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity.” Cell Chemical Biology 27, no. 7 (July 2020): 817-826.e5. https://doi.org/10.1016/j.chembiol.2020.06.004.
  • Posfai, Dora, Steven P. Maher, Camille Roesch, Amélie Vantaux, Kayla Sylvester, Julie Péneau, Jean Popovici, Dennis E. Kyle, Benoît Witkowski, and Emily R. Derbyshire. “Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3.” Cell Chemical Biology 27, no. 6 (June 2020): 719-727.e5. https://doi.org/10.1016/j.chembiol.2020.03.009.
  • Raphemot, Rene, Maria Toro-Moreno, Kuan-Yi Lu, Dora Posfai, and Emily Rose Derbyshire. “Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection.” Cell Chemical Biology 26, no. 9 (September 2019): 1253-1262.e5. https://doi.org/10.1016/j.chembiol.2019.05.011.