Aravind Asokan

Professor in Surgery

Synthetic Virology & Gene Therapy

Appointments and Affiliations

  • Professor in Surgery
  • Director of Gene Therapy
  • Professor of Biomedical Engineering
  • Professor of Molecular Genetics and Microbiology
  • Affiliate of the Duke Regeneration Center

Contact Information

Education

  • Ph.D. University of North Carolina, Chapel Hill, 2004

Research Interests

Virology
RNA Biology
Viral Engineering
RNA Engineering
Gene Therapy
Gene Editing
Gene Regulation
Regenerative Medicine

Courses Taught

  • MGM 593: Research Independent Study
  • BME 791: Graduate Independent Study
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Smith, Timothy J., Zachary C. Elmore, Robert M. Fusco, Joshua A. Hull, Alan Rosales, Michele Martinez, Alice F. Tarantal, and Aravind Asokan. “Engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer.” Mol Ther 32, no. 7 (July 3, 2024): 2080–93. https://doi.org/10.1016/j.ymthe.2024.05.004.
  • Karpurapu, Anish, Helen A. Williams, Paige DeBenedittis, Caroline E. Baker, Simiao Ren, Michael C. Thomas, Anneka J. Beard, et al. “Deep Learning Resolves Myovascular Dynamics in the Failing Human Heart.” JACC Basic Transl Sci 9, no. 5 (May 2024): 674–86. https://doi.org/10.1016/j.jacbts.2024.02.007.
  • Gao, Qimeng, Riley Kahan, Trevor J. Gonzalez, Min Zhang, Isaac S. Alderete, Isabel DeLaura, Samuel J. Kesseli, et al. “Gene delivery followed by ex vivo lung perfusion using an adeno-associated viral vector in a rodent lung transplant model.” J Thorac Cardiovasc Surg 167, no. 5 (May 2024): e131–39. https://doi.org/10.1016/j.jtcvs.2023.08.047.
  • Loeb, Ezra J., Patrick L. Havlik, Zachary C. Elmore, Alan Rosales, Sophia M. Fergione, Trevor J. Gonzalez, Timothy J. Smith, Abigail R. Benkert, David N. Fiflis, and Aravind Asokan. “Capsid-mediated control of adeno-associated viral transcription determines host range.” Cell Rep 43, no. 3 (March 26, 2024): 113902. https://doi.org/10.1016/j.celrep.2024.113902.
  • Zhu, Xiaoyi, Qiang Huang, Laiming Jiang, Van-Tu Nguyen, Tri Vu, Garth Devlin, Jabbar Shaima, et al. “Longitudinal intravital imaging of mouse placenta.” Sci Adv 10, no. 12 (March 22, 2024): eadk1278. https://doi.org/10.1126/sciadv.adk1278.