Effective delivery of therapeutics is a major problem in today’s healthcare. For example, in the case of protein and peptide drugs such as insulin, growth hormones, and vaccines, a key challenge is their stabilization and delivery without having to use needles. All proteins are currently delivered by needles, which have several limitations including pain, needle-phobia, and contamination caused by dirty needles. Our laboratory is addressing this challenge by delivering proteins using transdermal patches and oral pills. Neither of these routes is inherently suited for protein delivery since they offer significant diffusive and enzymatic barriers for protein transport. We have developed a number of technologies that overcome these barriers to deliver proteins for the treatment of diabetes, osteoporosis, psoriasis and several other diseases. I will present an overview of these technologies with respect to their principles and applications. Targeting of drugs to specific tissues is also a key challenge in therapeutic delivery. This is especially problematic for cancer and cardiovascular diseases, where the effectiveness of drugs is limited by their poor accumulation at the disease tissue and high accumulation in healthy tissues. Our laboratory is developing nanoparticles that can encapsulate chemotherapeutic drugs and target them to tumors. Our strategy explores biomimetic designs that leverage the principles of natural cells such as platelets and red blood cells to accomplish excellent targeting. I will present an overview of some the targeting strategies for the treatment of breast cancer and vascular bleeding after trauma.
Dr. Samir Mitragotri is a Professor of Chemical Engineering at the University of California, Santa Barbara (UCSB). He is also the founding Director of the Center for Bioengineering at UCSB, Professor Mitragotri received Ph.D. from MIT in 1996 and B.S. from the Institute of Chemical Technology, Mumbai in 1992, both in Chemical Engineering. Professor Mitragotri has pioneered new technologies to deliver medicines without using needles. Effective delivery of medicines to patients for the treatment of life-threatening diseases is a major problem, especially for biopharmaceutical drugs (large molecules) that are increasingly dominating the repertoire of pharmaceutical products. Currently, these drugs have to be delivered by injections. Professor Mitragotri has addressed this challenge by developing innovative technologies for needle-free drug delivery via skin patches and oral pills which are easy-to-use, patient-friendly, and safe. In addition, Prof. Mitragotri has also pioneered new methods of targeted drug delivery for the treatment of cancer and vascular diseases. His methods provide targeting methologies to tumors and vascular lesions that open new therapeutic opportunitues. He has also published nearly 200 papers on drug delivery in leading journals.