BioE Seminar Series:Dissecting Cell-Specific, Matrix-Mediated Contributions to Fibrosis using New Biomaterials and Microphysiologic Models
Thursday, March 24, 2022
12:00 pm - 1:00 pm
Brendon Baker, PhD, Assistant Professor, Department of Biomedical Engineering, University of Michigan
During fibrotic diseases, functional tissue parenchyma progressively transform into stiff, disorganized, and non-functional tissue to cause organ failure. Underlying this transition are a multitude of interconnected changes in the cellular microenvironment that can only be understood by using new approaches to interrogate cells within appropriate biomaterial settings. In this talk, I'll highlight recent efforts from my group to bioengineer 3D models of myofibroblast-driven tissue remodeling and microvascular dysregulation associated with the fibrotic progression.