BioE Seminar: Genome Engineering for Synthetic Genomics and Cell Engineering
Thursday, February 11, 2021
12:00 pm - 1:00 pm
Stanley Qi, PhD, Assistant Professor, Departments of Bioengineering and Chemical & Systems Biology, Stanford University
Synthetic manipulation of the genome is important for understanding the genetics of living organisms and developing better therapy. Beyond gene editing, we've seen significant CRISPR technology development for controlling and studying many aspects of the genome. Towards this goal, we've developed the nuclease-dead Cas (dCas) system, repurposed from the bacterial Cas nuclease, and demonstrated the use of dCas for transcription regulation, epigenetic modifications, and the 3D genome control. We are particularly interested in applying genome engineering technologies to understand the noncoding content that occupies 98% of our genome. Furthermore, we continue to explore how CRISPR tools can facilitate development of novel gene therapy. In this talk, I will cover several areas that we worked on to expand the CRISPR technology on understanding the noncoding genome and synthetic biology. Email Michael Humphreys (firstname.lastname@example.org) for Zoom information.