Michael D Lynch

Image of Michael D Lynch

Assistant Professor in the Department of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor in the Department of Biomedical Engineering
  • Faculty Fellow in The Energy Initiative
  • Associate of the Duke Initiative for Science & Society

Contact Information:


  • M.D. University of Colorado School of Medicine, 2007
  • Ph.D. University of Colorado - Boulder, 2005

Research Interests:

Focused on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds—improving production of biofuels, pharmacological molecules and industrial chemicals.

Courses Taught:

  • BME 490L: Special Topics in Biomedical Engineering Design (DR)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590D: Special Topics with Discussion
  • BME 590L: Special Topics with Lab
  • BME 703S: Engineering Management Seminar for Master of Science Students
  • BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • EGR 393: Research Projects in Engineering
  • ISS 293: ISS Research Independent Study
  • ISS 391: Bass Connections in Information Science and Culture: Independent Study Project
  • ISS 795: Connections in Information, Society and Culture: Project

Representative Publications:

  • Menacho-Melgar, R; Moreb, EA; Efromson, JP; Yang, T; Hennigan, JN; Wang, R; Lynch, MD, Improved two-stage protein expression and purification via autoinduction of both autolysis and auto DNA/RNA hydrolysis conferred by phage lysozyme and DNA/RNA endonuclease., Biotechnology and Bioengineering, vol 117 no. 9 (2020), pp. 2852-2860 [10.1002/bit.27444] [abs].
  • Decker, JS; Menacho-Melgar, R; Lynch, MD, Low-Cost, Large-Scale Production of the Anti-viral Lectin Griffithsin, Frontiers in Bioengineering and Biotechnology, vol 8 (2020) [10.3389/fbioe.2020.01020] [abs].
  • Li, S; Moreb, E; Ye, Z; Hennigan, J; Castellanos, DB; Yang, T; Lynch, M, Dynamic control over feedback regulatory mechanisms improves NADPH fluxes and xylitol biosynthesis in engineered E. coli (2020) [10.1101/2020.07.27.222588] [abs].
  • Ye, Z; Lebeau, J; Moreb, E; Menacho-Melgar, R; Lynch, M, The E. coli Cas1/2 endonuclease complex reduces CRISPR/Cascade guide array stability (2020) [10.1101/2020.07.27.223214] [abs].
  • Li, S; Ye, Z; Lebeau, J; Moreb, E; Lynch, M, Dynamic control over feedback regulation identifies pyruvate-ferredoxin oxidoreductase as a central metabolic enzyme in stationary phase E. coli (2020) [10.1101/2020.07.26.219949] [abs].