Michael D Lynch


Assistant Professor in the Department of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor in the Department of Biomedical Engineering
  • Assistant Professor of Chemistry
  • Faculty Fellow in The Energy Initiative
  • Associate of the Duke Initiative for Science & Society

Contact Information


  • M.D. University of Colorado School of Medicine, 2007
  • Ph.D. University of Colorado - Boulder, 2005

Research Interests

Focused on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds—improving production of biofuels, pharmacological molecules and industrial chemicals.

Awards, Honors, and Distinctions

    Courses Taught

    • BME 490L: Special Topics in Biomedical Engineering Design (DR)
    • BME 590D: Special Topics with Discussion
    • BME 590L: Special Topics with Lab
    • BME 703S: Engineering Management Seminar for Master of Science Students
    • BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering

    In the News

    Representative Publications

    • Hennigan, JN; Lynch, MD, The past, present, and future of enzyme-based therapies., Drug Discovery Today, vol 27 no. 1 (2022), pp. 117-133 [10.1016/j.drudis.2021.09.004] [abs].
    • Menacho-Melgar, R; Hennigan, JN; Lynch, MD, Optimization of phosphate-limited autoinduction broth for two-stage heterologous protein expression in Escherichia coli., Biotechniques, vol 71 no. 5 (2021), pp. 566-572 [10.2144/btn-2021-0055] [abs].
    • Ye, Z; Li, S; Hennigan, JN; Lebeau, J; Moreb, EA; Wolf, J; Lynch, MD, Two-stage dynamic deregulation of metabolism improves process robustness & scalability in engineered E. coli., Metabolic Engineering, vol 68 (2021), pp. 106-118 [10.1016/j.ymben.2021.09.009] [abs].
    • Moreb, EA; Lynch, MD, Genome dependent Cas9/gRNA search time underlies sequence dependent gRNA activity., Nature Communications, vol 12 no. 1 (2021) [10.1038/s41467-021-25339-3] [abs].
    • Rios, J; Lebeau, J; Yang, T; Li, S; Lynch, MD, A critical review on the progress and challenges to a more sustainable, cost competitive synthesis of adipic acid, Green Chem., vol 23 no. 9 (2021), pp. 3172-3190 [10.1039/d1gc00638j] [abs].