Michael D Lynch

Image of Michael D Lynch

Assistant Professor in the Department of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor in the Department of Biomedical Engineering
  • Faculty Fellow in The Energy Initiative
  • Associate of the Duke Initiative for Science & Society

Contact Information:


  • M.D. University of Colorado School of Medicine, 2007
  • Ph.D. University of Colorado at Boulder, 2005

Research Interests:

Focused on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds—improving production of biofuels, pharmacological molecules and industrial chemicals.

Courses Taught:

  • BME 490L: Special Topics in Biomedical Engineering Design (DR)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590L: Special Topics with Lab
  • BME 703S: Engineering Management Seminar for Master of Science Students
  • BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • EGR 393: Research Projects in Engineering
  • ISS 293: ISS Research Independent Study
  • ISS 391: Bass Connections in Information Science and Culture: Independent Study Project
  • ISS 795: Connections in Information, Society and Culture: Project

Representative Publications:

  • Menacho-Melgar, R; Decker, JS; Hennigan, JN; Lynch, MD, A review of lipidation in the development of advanced protein and peptide therapeutics., Journal of Controlled Release : Official Journal of the Controlled Release Society, vol 295 (2019), pp. 1-12 [10.1016/j.jconrel.2018.12.032] [abs].
  • Moreb, EA; Hoover, B; Yaseen, A; Valyasevi, N; Roecker, Z; Menacho-Melgar, R; Lynch, MD, Managing the SOS Response for Enhanced CRISPR-Cas-Based Recombineering in E. coli through Transient Inhibition of Host RecA Activity., Acs Synthetic Biology, vol 6 no. 12 (2017), pp. 2209-2218 [10.1021/acssynbio.7b00174] [abs].
  • Burg, JM; Cooper, CB; Ye, Z; Reed, BR; Moreb, EA; Lynch, MD, Large-scale bioprocess competitiveness: the potential of dynamic metabolic control in two-stage fermentations, Current Opinion in Chemical Engineering, vol 14 (2016), pp. 121-136 [10.1016/j.coche.2016.09.008] [abs].
  • Lynch, MD, Into new territory: improved microbial synthesis through engineering of the essential metabolic network., Current Opinion in Biotechnology, vol 38 (2016), pp. 106-111 [10.1016/j.copbio.2016.01.009] [abs].
  • Lynch, MD, A rational microbial design perspective in the design build test era, Metabolic Engineering X (2014), pp. 505-528 [abs].