Michael C. Fitzgerald

Image of Michael C. Fitzgerald

Professor of Chemistry

Dr. Fitzgerald’s research group is focused on studies of protein folding and function. The group utilizes a combination of covalent labeling strategies (e.g. protein amide H/D exchange and methionine oxidiation) and mass spectrometry techniques to investigate the thermodynamic properties of protein folding and ligand binding reactions. Current research efforts involve: (1) the development new biophysical methods that enable protein folding and stability measurements to be performed on the proteomic scale; and (2) the application of these new methods in the areas of disease detection, diagnosis, and therapy.

Appointments and Affiliations

  • Professor of Chemistry
  • Professor of Biochemistry

Contact Information:

  • Office Location: 3222 French Science Center, 124 Science Drive, Durham, NC 27708
  • Office Phone: (919) 660-1547
  • Email Address: michael.c.fitzgerald@duke.edu
  • Web Page:


  • Ph.D. University of Wisconsin at Madison, 1994
  • B.S. Davidson College, 1989

Awards, Honors, and Distinctions:

  • Presidential Early Career Awards for Scientists and Engineers. President of the United States of America. 2001

Courses Taught:

  • BIOCHEM 593: Research Independent Study
  • CHEM 393: Research Independent Study
  • CHEM 394: Research Independent Study
  • CHEM 401: Analytical Chemistry
  • CHEM 401L: Analytical Chemistry Laboratory
  • CHEM 493: Research Independent Study
  • CHEM 494: Research Independent Study
  • CHEM 506: Biomolecular Mass Spectrometry
  • CHEM 701S: Research Orientation Seminar
  • CHEM 801: Research

Representative Publications:

  • Ogburn, RN; Jin, L; Meng, H; Fitzgerald, MC, Discovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements., Journal of Proteome Research, vol 16 no. 11 (2017), pp. 4073-4085 [10.1021/acs.jproteome.7b00442] [abs].
  • Liu, F; Meng, H; Fitzgerald, MC, Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX., Journal of Proteome Research, vol 16 no. 9 (2017), pp. 3277-3286 [10.1021/acs.jproteome.7b00283] [abs].
  • Lim, KH; Dasari, AKR; Ma, R; Hung, I; Gan, Z; Kelly, JW; Fitzgerald, MC, Pathogenic Mutations Induce Partial Structural Changes in the Native β-Sheet Structure of Transthyretin and Accelerate Aggregation., Biochemistry, vol 56 no. 36 (2017), pp. 4808-4818 [10.1021/acs.biochem.7b00658] [abs].
  • Randall, TA; London, RE; Fitzgerald, MC; Mueller, GA, Proteases of Dermatophagoides pteronyssinus., International journal of molecular sciences, vol 18 no. 6 (2017) [10.3390/ijms18061204] [abs].
  • Ogburn, RN; Randall, TA; Xu, Y; Roberts, JH; Mebrahtu, B; Karnuta, JM; Rider, SD; Kissling, GE; London, RE; Pomés, A; Arlian, L; Fitzgerald, MC; Mueller, GA, Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?, Journal of Allergy and Clinical Immunology, vol 139 no. 3 (2017), pp. 1030-1032.e1 [10.1016/j.jaci.2016.08.016] [abs].