Emily Rose Derbyshire

Image of Emily R. Derbyshire

Assistant Professor of Chemistry

The Derbyshire Lab uses both chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens to exploring biological pathways and identifying small molecules with potential therapeutic value. Their interdisciplinary collaborative program integrates chemical biology, molecular biology and biochemistry to globally interrogate parasite biology.

Appointments and Affiliations

  • Assistant Professor of Chemistry
  • Assistant Professor in Molecular Genetics and Microbiology

Contact Information:

  • Office Location: 3218 French Science Center, Durham, NC 27708
  • Office Phone: (919) 660-1511
  • Email Address: emily.derbyshire@duke.edu
  • Web Page:

Education:

  • Harvard Medical School, 2014
  • Ph.D. University of California - Berkeley, 2008
  • B.S. Trinity College, 2002

Courses Taught:

  • CHEM 89S: First-Year Seminar
  • CHEM 393: Research Independent Study
  • CHEM 394: Research Independent Study
  • CHEM 493: Research Independent Study
  • CHEM 494: Research Independent Study
  • CHEM 517: Molecules in Life and Disease
  • MGM 293: Research Independent Study I
  • MGM 593: Research Independent Study
  • PHARM 693: Research Independent Study in Science Education

Representative Publications:

  • Ganley, JG; Pandey, A; Sylvester, K; Lu, K-Y; Toro-Moreno, M; Rütschlin, S; Bradford, JM; Champion, CJ; Böttcher, T; Xu, J; Derbyshire, ER, A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity., Cell Chemical Biology, vol 27 no. 7 (2020), pp. 817-826.e5 [10.1016/j.chembiol.2020.06.004] [abs].
  • Posfai, D; Maher, SP; Roesch, C; Vantaux, A; Sylvester, K; Péneau, J; Popovici, J; Kyle, DE; Witkowski, B; Derbyshire, ER, Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3., Cell Chemical Biology, vol 27 no. 6 (2020), pp. 719-727.e5 [10.1016/j.chembiol.2020.03.009] [abs].
  • Ganley, JG; D'Ambrosio, HK; Shieh, M; Derbyshire, ER, Coculturing of Mosquito-Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anophelis., Chembiochem : a European Journal of Chemical Biology, vol 21 no. 9 (2020), pp. 1279-1284 [10.1002/cbic.201900675] [abs].
  • Lu, K-Y; Quan, B; Sylvester, K; Srivastava, T; Fitzgerald, MC; Derbyshire, ER, Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy., Proceedings of the National Academy of Sciences of the United States of America, vol 117 no. 11 (2020), pp. 5810-5817 [10.1073/pnas.1913525117] [abs].
  • Lu, K-Y; Derbyshire, ER, Tafenoquine: A Step toward Malaria Elimination., Biochemistry, vol 59 no. 8 (2020), pp. 911-920 [10.1021/acs.biochem.9b01105] [abs].