Ashutosh Chilkoti

Image of Ashutosh Chilkoti

Alan L. Kaganov Professor of Biomedical Engineering

Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University.

My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.

Appointments and Affiliations

  • Alan L. Kaganov Professor of Biomedical Engineering
  • Professor of Biomedical Engineering
  • Chair of the Department of Biomedical Engineering
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Chemistry
  • Member of the Duke Cancer Institute

Contact Information:

Education:

  • Ph.D. University of Washington, 1991

Awards, Honors, and Distinctions:

  • Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015
  • Fellow. National Academy of Inventors. 2014
  • Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013
  • Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
  • Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
  • Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010
  • Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008
  • Fellow. American Institute for Medical and Biological Engineering. 1996

Courses Taught:

  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 570L: Introduction to Biomolecular Engineering (GE, BB, MC)
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • BME 899: Special Readings in Biomedical Engineering
  • CHEM 393: Research Independent Study
  • CHEM 394: Research Independent Study
  • CHEM 493: Research Independent Study
  • EGR 393: Research Projects in Engineering
  • EGR 491: Projects in Engineering
  • NEUROSCI 493: Research Independent Study 1
  • NEUROSCI 494: Research Independent Study 2

Representative Publications:

  • Joh, DY; Hucknall, AM; Wei, Q; Mason, KA; Lund, ML; Fontes, CM; Hill, RT; Blair, R; Zimmers, Z; Achar, RK; Tseng, D; Gordan, R; Freemark, M; Ozcan, A; Chilkoti, A, Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood., Proceedings of the National Academy of Sciences of USA, vol 114 no. 34 (2017), pp. E7054-E7062 [10.1073/pnas.1703200114] [abs].
  • Luginbuhl, KM; Schaal, JL; Umstead, B; Mastria, EM; Li, X; Banskota, S; Arnold, S; Feinglos, M; D'Alessio, D; Chilkoti, A, One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer., vol 1 (2017) [10.1038/s41551-017-0078] [abs].
  • Tang, NC; Chilkoti, A, Combinatorial codon scrambling enables scalable gene synthesis and amplification of repetitive proteins., Nature Materials, vol 15 no. 4 (2016), pp. 419-424 [10.1038/nmat4521] [abs].
  • Qi, Y; Simakova, A; Ganson, NJ; Li, X; Luginbuhl, KM; Özer, I; Liu, W; Hershfield, MS; Matyjaszewski, K; Chilkoti, A, A brush-polymer conjugate of exendin-4 reduces blood glucose for up to five days and eliminates poly(ethylene glycol) antigenicity., vol 1 (2016) [10.1038/s41551-016-0002] [abs].
  • Quiroz, FG; Chilkoti, A, Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers., Nature Materials, vol 14 no. 11 (2015), pp. 1164-1171 [10.1038/nmat4418] [abs].
  • Bhattacharyya, J; Bellucci, JJ; Weitzhandler, I; McDaniel, JR; Spasojevic, I; Li, X; Lin, C-C; Chi, J-TA; Chilkoti, A, A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models., Nature Communications, vol 6 (2015) [10.1038/ncomms8939] [abs].
  • Amiram, M; Quiroz, FG; Callahan, DJ; Chilkoti, A, A highly parallel method for synthesizing DNA repeats enables the discovery of 'smart' protein polymers., Nature Materials, vol 10 no. 2 (2011), pp. 141-148 [10.1038/nmat2942] [abs].
  • MacKay, JA; Chen, M; McDaniel, JR; Liu, W; Simnick, AJ; Chilkoti, A, Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection, Nature Materials, vol 8 no. 12 (2009), pp. 993-999 [10.1038/NMAT2569] [abs].
  • Meyer, DE; Chilkoti, A, Purification of recombinant proteins by fusion with thermally-responsive polypeptides., Nature Biotechnology, vol 17 no. 11 (1999), pp. 1112-1115 [10.1038/15100] [abs].