Aravind Asokan


Professor in Surgery

Synthetic Virology & Gene Therapy

Appointments and Affiliations

  • Professor in Surgery
  • Director of Gene Therapy
  • Professor of Biomedical Engineering
  • Professor of Molecular Genetics and Microbiology
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Ph.D. University of North Carolina - Chapel Hill, 2004

Research Interests

RNA Biology
Viral Engineering
RNA Engineering
Gene Therapy
Gene Editing
Gene Regulation
Regenerative Medicine

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study
  • MGM 293: Research Independent Study I
  • MGM 593: Research Independent Study

In the News

Representative Publications

  • Yan, R; Cigliola, V; Oonk, KA; Petrover, Z; DeLuca, S; Wolfson, DW; Vekstein, A; Mendiola, MA; Devlin, G; Bishawi, M; Gemberling, MP; Sinha, T; Sargent, MA; York, AJ; Shakked, A; DeBenedittis, P; Wendell, DC; Ou, J; Kang, J; Goldman, JA; Baht, GS; Karra, R; Williams, AR; Bowles, DE; Asokan, A; Tzahor, E; Gersbach, CA; Molkentin, JD; Bursac, N; Black, BL; Poss, KD, An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair., Cell Stem Cell, vol 30 no. 1 (2023), pp. 96-111.e6 [10.1016/j.stem.2022.11.012] [abs].
  • Nyberg, WA; Ark, J; To, A; Clouden, S; Reeder, G; Muldoon, JJ; Chung, J-Y; Xie, WH; Allain, V; Steinhart, Z; Chang, C; Talbot, A; Kim, S; Rosales, A; Havlik, LP; Pimentel, H; Asokan, A; Eyquem, J, An evolved AAV variant enables efficient genetic engineering of murine T cells., Cell (2023) [10.1016/j.cell.2022.12.022] [abs].
  • Konkimalla, A; Konishi, S; Kobayashi, Y; Kadur Lakshminarasimha Murthy, P; Macadlo, L; Mukherjee, A; Elmore, Z; Kim, S-J; Pendergast, AM; Lee, PJ; Asokan, A; Knudsen, L; Bravo-Cordero, JJ; Tata, A; Tata, PR, Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration., Iscience, vol 25 no. 10 (2022) [10.1016/j.isci.2022.105114] [abs].
  • Gonzalez, TJ; Simon, KE; Blondel, LO; Fanous, MM; Roger, AL; Maysonet, MS; Devlin, GW; Smith, TJ; Oh, DK; Havlik, LP; Castellanos Rivera, RM; Piedrahita, JA; ElMallah, MK; Gersbach, CA; Asokan, A, Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing., Nature Communications, vol 13 no. 1 (2022) [10.1038/s41467-022-33745-4] [abs].
  • Das, A; Vijayan, M; Walton, EM; Stafford, VG; Fiflis, DN; Asokan, A, Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex., J Virol, vol 96 no. 4 (2022) [10.1128/JVI.02039-21] [abs].