BioE Seminar Series: Cell Migration and Morphogenesis in Viscoelastic Matrices

Thursday, April 13, 2023

12:00 pm - 1:00 pm
CIEMAS Bldg: Schiciano B

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Presenter

Ovijit Chaudhuri, PhD, Associate Professor, Departments of Mechanical Engineering, and Bioengineering, Stanford University

The extracellular matrix (ECM) is a complex assembly of structural proteins that provides physical support and biochemical signaling to cells in tissues. Over the last two decades, studies have revealed the important role that ECM elasticity plays in regulating a variety of biological processes in cells, including stem cell differentiation and cancer progression. However, tissues and ECM are often viscoelastic, displaying stress relaxation over time in response to a deformation, and viscoplastic, exhibiting irreversible deformations in response to mechanical stress. In this talk, I will discuss our recent findings on how matrix viscoelasticity regulates various biological processes, including collective invasion by cancer cells and the morphogenesis of pluripotent stem cells.

Contact

Michael Humphreys
michael.humphreys@duke.edu